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Poloxalene

Polyethylene-polypropylene Glycol / Poloxamer 188 Cas 9003-11-6

CAS No.:9003-11-6
Purity:99%
Place of Origin:Henan China
MF:C17H33COO(CH2CH2O)nH
Appearance:Amber liquid
Certification:MSDS,COA,TDS
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Poloxamer is a class of nonionic block copolymer surfactants composed of polyethylene oxide (PEO) and polypropylene oxide (PPO). Its molecular structure is typically a triblock structure with hydrophilic ends and a hydrophobic middle. These substances exhibit unique amphiphilic properties, being soluble in both water and organic solvents, and display a significant “reverse thermogel” characteristic, meaning they are liquid at low temperatures and transform into a gel at high temperatures. Poloxamer is widely used in the pharmaceutical, chemical, and biotechnology fields as an emulsifier, solubilizer, stabilizer, and drug carrier. Common types include poloxamer 188 and poloxamer 407.

Product picture:
Polyethylene-polypropylene glycol factory
Polyethylene polypropylene glycol factory

 

Function

In pharmaceutical formulations, poloxamer 188 is commonly used as an emulsifier in intravenous fat emulsions (such as propofol injection) and as a solubilizer for poorly soluble drugs, improving bioavailability. Utilizing its thermosensitive properties, poloxamer 407 has been developed into in-situ gel systems for ophthalmic, nasal, and injectable applications, achieving long-acting sustained release of drugs. Furthermore, in protein drugs and vaccines, poloxamer 188 acts as a stabilizer, preventing protein aggregation and interfacial denaturation.

In cosmetics, poloxamer is commonly used as an emulsifier, solubilizer, and mild surfactant. For example, in makeup removers and facial cleansers, its micellar solubilization technology dissolves oils; in toothpaste and mouthwash, its gel properties improve taste and stability.

In cell culture, poloxamer 188 (Pluronic F68) is widely used as a shear protectant, reducing cell damage caused by shear forces generated by bioreactor agitation, thereby improving cell viability and product expression levels.

 

Technical Specifications:

Model
Appearance
Colority Pt-Co
Hydroxyl value mg KOH/g
Molecular weight
Ice point ℃
Water content %
PH value (1% water solution)
PEG-200
transparent liquid Colorless
≤20
510-623
180-220
—
≤1.0
5.0-7.0
PEG-300
transparent liquid Colorless
≤20
340-416
270-330
—
≤1.0
5.0-7.0
PEG-400
transparent liquid Colorless
≤20
255-312
360-440
4-10
≤1.0
5.0-7.0
PEG-600
transparent liquid Colorless
≤20
170-208
540-660
20-25
≤1.0
5.0-7.0
PEG-800
Milky white cream
≤30
127-156
720-880
26-32
≤1.0
5.0-7.0
PEG-1000
Milky white solid
≤40
102-125
900-1100
38-41
≤1.0
5.0-7.0
PEG-1500
Milky white solid
≤40
68-83
1350-1650
43-46
≤1.0
5.0-7.0
PEG-2000
Milky white solid
≤50
51-63
1800-2200
48-50
≤1.0
5.0-7.0
PEG-3000
Milky white solid
≤50
34-42
2700-3300
51-53
≤1.0
5.0-7.0
PEG-4000
Milky white solid
≤50
26-32
3600-4400
53-54
≤1.0
5.0-7.0
PEG-6000
Milky white solid
≤50
17.5-20
5500-7000
54-60
≤1.0
5.0-7.0
PEG-8000
Milky white solid
≤50
12-16
7200-8800
55-63
≤1.0
5.0-7.0
PEG-10000
Milky white solid
≤50
9.4-12.5
9000-120000
55-63
≤1.0
5.0-7.0
PEG-20000
Milky white solid
≤50
5-6.5
18000-22000
55-63
≤1.0
5.0-7.0

 

Package:

1kg / 200kg Bucket

Palletized Shipping

Lead Time: 1-7 Days

Shipping Methods: Sea/Air/Express delivery

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