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2-Bromopyridine

2-Bromopyridine CAS 109-04-6

CAS No.:109-04-6
Purity:99%
Place of Origin:Henan China
MF:C5H4BrN
Appearance:Clear colorless to pale brown Liquid
Certification:MSDS,COA,TDS
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2-Bromopyridine, also known as o-bromopyridine or α-bromozabenzene, is an important organic synthesis intermediate with the chemical formula C₅H₄BrN. It is a derivative in which the hydrogen atom at the 2-position of the pyridine ring is replaced by a bromine atom. It is typically a colorless to pale yellow oily liquid with a characteristic aromatic odor. 2-Bromopyridine has wide applications in pharmaceuticals, pesticides, dyes, and materials science. In the pharmaceutical industry, it is a key intermediate in the synthesis of many drugs (such as diisopropylpyridine and atazanavir). In organic synthesis, it is often used as a building block for constructing complex heterocyclic compounds or as a ligand in transition metal-catalyzed reactions. Due to the presence of an active bromine atom and a pyridine ring in its molecule, 2-Bromopyridine readily undergoes nucleophilic substitution, coupling, and metal coordination reactions, making it a fundamental raw material in medicinal chemistry and coordination chemistry.

 

Product picture:
2-Bromopyridine
2 Bromopyridine
Function

2-Bromopyridine is a key building block in the synthesis of many drugs, widely used in constructing nitrogen-containing heterocyclic drug molecule skeletons. In the cardiovascular drug field, it is an important raw material for the synthesis of the antiarrhythmic drug disopyramide (disopyramide phosphate), commonly used to treat arrhythmias. In the antiviral and anticancer drug field, 2-bromopyridine is used to synthesize the protease inhibitor atazanavir, an antiretroviral drug used to treat HIV. Furthermore, it can be used to synthesize other antitumor, antiviral, and antibacterial drugs. In target-based drug design, 2-bromopyridine is often used to introduce pyridine pharmacophores, regulating the drug’s lipophilicity, solubility, and binding affinity to target proteins.

2-Bromopyridine plays an important role in agricultural chemical production as an intermediate in the synthesis of various insecticides, herbicides, and fungicides. For example, it is used to synthesize novel insecticides and herbicides, and its derivatives exhibit significant insecticidal and herbicidal activities in agricultural production. It is also used to synthesize specific pyridine dyes, which are widely used in the textile and dyeing industries.

2-Bromopyridine and its derivatives are important organic ligands. They can form complexes with transition metals and are used to catalyze C-H activation, coupling reactions, and other organic synthetic transformations. Furthermore, some metal complexes containing the 2-bromopyridine structure (such as ruthenium and iridium complexes) possess unique photophysical properties and can be used to develop organic light-emitting diodes (OLEDs), chemical sensors, and photodynamic therapy reagents.

 

Technical Specifications:

Appearance
Clear colorless to pale brown Liquid
Content
99% min(GC)
M.P.
193°C
Moisture
0.20% max

 

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1Kg / 25Kg Bucket

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Lead Time: 1-7 Days

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2-Bromopyridine package
2 Bromopyridine package

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